Description: Preface... Table of Contents... Contributing Authors... 1. Library Synthesis: Building Block Selection, Handling, and Tracking Katelyn J. Billings and Melissa C. Grenier-Davies 2. Library Synthesis: Building Block Validation Melissa C. Grenier-Davies 3. Library Synthesis and Analytics Jing Chai 4. Chemical Ligation of Oligonucleotide Tags to Support Encoded Chemical Library Synthesis Alexander Litovchick and Anthony D. Keefe 5. On-DNA Reductive Amination and Alkylation Jing Chai 6. On-DNA-1,2,3-Triazole Formation via Click Reaction Sarah K. Scott 7. On-DNA Suzuki-Miyaura Cross-Coupling Yun Ding 8. On-DNA Pd and Cu Promoted C-N Cross-Coupling Reactions Xiaojie Lu and Xuan Wang 9. Palladium Promoted On-DNA Heck Reactions Xuan Wang and Xiaojie Lu 10. Ruthenium Promoted On-DNA C-H Activation Reaction Xuan Wang and Xiaojie Lu 11. DNA-Compatible Nitro Reduction and Synthesis of Benzimidazoles Huang-Chi Du, Ying-Chu Chen, and Hongbing Huang 12. Condensation of DNA-Conjugated Imines with Homophthalic Anhydride for the Synthesis of Isoquinolones On-DNA Josephine Yuen, Jing Chai, and Yun Ding 13. DNA Encoding of Natural Products Hongtao Xu and Peixiang Ma 14. Initiating DNA-Encoded Library Synthesis with a Hexathymidine DNA Oligonucleotide Mateja Klika skopic, Denise dos Santos Smith, Anne Gohla, Verena B. K. Kunig, and Andreas Brunschweiger 15. One Bead-One Compound (OBOC) Peptidomimetic Encoded Library Synthesis via Split-and-Pool Methods Claudio Aquino and Mohosin Sarkar 16. DNA Conjugates as Tool Compounds for DEL Selections David I. Israel 17. Quantitation of DNA Encoded Libraries by qPCR Christopher S. Kollmann 18. Target Protein Design and Pre-Selection Analysis Qiuxia Chen and David I. Israel 19. DEL Selections Against a Soluble Protein Target Qiuxia Chen and Junyang Zhu 20. Selection Method of DNA-Encoded Chemical Library for Irreversible Covalent Binders Zhengrong Zhu 21. Next Generation Sequencing of DNA-Encoded Libraries Jian Liu and You Li 22. Translation of DNA Sequence to Chemical Structure in DNA Encoded Libraries You Li 23. Analysis of DNA-Encoded Library Screening Data: Selection of Molecules for Synthesis Alexander L. Satz and Weiren Cui 24. High Throughput Binder Confirmation (HTBC) Bing Xia and Jennifer D. Summerfield 25. High-Throughput Binder Confirmation Using Affinity Selection Mass Spectrometry Eric X. Shi Subject Index List...
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EAN: 9781071625446
UPC: 9781071625446
ISBN: 9781071625446
MPN: N/A
Format: Hardback, 226 pages, 2022 Edition
Author: David Israel (Edited by)
Item Height: 1.4 cm
Item Length: 25.4 cm
Item Weight: 0.65 kg
Item Width: 17.8 cm
Language: Eng
Publication Name: N/A
Publisher: Springer-Verlag New York Inc.
Type: N/A
