Description: Cancer Cell Signaling Please note: this item is printed on demand and will take extra time before it can be dispatched to you (up to 20 working days). Methods and Protocols Author(s): David M. Terrian Format: Paperback Publisher: Humana Press Inc., United States Imprint: Humana Press Inc. ISBN-13: 9781617373411, 978-1617373411 Synopsis Cells respond to environmental cues through a complex and dynamic network of signaling pathways that normally maintain a critical balance between cellular proliferation, differentiation, senescence, and death. One current research challenge is to identify those aberrations in signal transd- tion that directly contribute to a loss of this division-limited equilibrium and the progression to malignant transformation. The study of cell-signaling m- ecules in this context is a central component of cancer research. From the knowledge of such targets, investigators have been able to productively advance many insightful hypotheses about how a particular cancer cell may misinterpret, or respond inappropriately to, growth regulatory cues in their environment. Despite these key insights, the rapidly evolving nature of cell signaling research in cancer has necessitated a continuous revision of these theoretical constructs and the updating of methods used in their study. One contemporary example of the evolution of this field is provided by an analysis of the Human Genome Project data, which reveal a previously unsuspected diversity in the multigene families encoding for most signaling pathway int- mediates. In assessing the usefulness of a particular methodological approach, therefore, we will need to keep in mind that there is a premium on those p- tocols that can be easily adapted for the analysis of multiple members within a gene family. Cancer Cell Signaling: Methods and Protocols brings together several such methods in cell signaling research that are scientifically grounded within the cancer biology field.
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Book Title: Cancer Cell Signaling
Item Height: 229 mm
Item Width: 152 mm
Series: Methods in Molecular Biology
Author: David M. Terrian
Publication Name: Cancer Cell Signaling: Methods and Protocols
Format: Paperback
Language: English
Publisher: Humana Press Inc.
Subject: Medicine
Publication Year: 2010
Type: Textbook
Item Weight: 526 g
Number of Pages: 333 Pages
